Glutathione, often dubbed the master antioxidant plays a crucial role in detoxification, immune function, and protecting our cells from oxidative stress. Here are some signs that your levels might be low: Persistent Your Complete Guide to Glutathione Schoenwalder Health & Wellness Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Engineering nanomedicine for glutathione depletion augmented cancer therapy Chemical Society Reviews (RSC Publishing)