What is glutathione and why must we protect patient access to it? Engineering nanomedicine for glutathione depletion augmented cancer therapy Chemical Society Reviews (RSC Publishing) Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which Glutathione depletion induces oxidative injury and apoptosis via TRPM2 channel activation in renal collecting duct cells ScienceDirect