Could Tylenol be making your child's health worse? Acetaminophen is widely used for pain and fever relief, but research suggests it depletes glutathione, a powerful antioxidant essential for immune function, Glutathione depletion induces oxidative injury and apoptosis via TRPM2 channel activation in renal collecting duct cells ScienceDirect Glutathione, often dubbed the master antioxidant plays a crucial role in detoxification, immune function, and protecting our cells from oxidative stress. Here are some signs that your levels might be low: Persistent Not only that, it depletes your #glutathione levels!