Mycotoxins are toxic. But they are only one of many stressors affecting the extracellular matrix. Ochratoxin, aflatoxins, and trichothecenes increase oxidative stress, deplete glutathione, disrupt mitochondria, and activate inflammatory signaling. That Glutathione depleting Liposome Adjuvant for Augmenting the Efficacy of a Glutathione Covalent Inhibitor Oridonin for Acute Myeloid Leukemia Therapy Journal of Nanobiotechnology Springer Nature Link Redox Directed Cancer Therapeutics: Molecular Mechanisms and Opportunities Georg T. Wondrak, 2009 Glutathione IV Detox Your Shortcut to Feeling Fabulous
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mycotoxins deplete glutathione Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion