Liver injury induced by paracetamol and challenges associated with intentional and unintentional use What Is Acetaminophen? Definition, Uses, Side Effects, and Risks Olympic Behavioral Health Frontiers Paracetamol Induced Glutathione Consumption: Is There a Link With Severe COVID 19 Illness? Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.