Brittany Xavier here's two reasons why we don't personally use Tylenol or acetaminophen Instagram Impaired Sulfate Metabolism and Epigenetics: Is There a Link in Autism? Here's how to make Tylenol work way better Dose it correctly: 1,000 mg at a time, spaced every 8 hours. Smaller doses don't control pain as well. Take it Tylenol uses up the liver's stores of GLUTATHIONE. Glutathione is the body's most important ANTIOXIDANT.