Can paracetamol (acetaminophen) be administered to patients with liver impairment? Hayward 2016 British Journal of Clinical Pharmacology Wiley Online Library Tylenol's Impact on Glutathione and Liver Damage Researchers are studying a possible link between acetaminophen (Tylenol) use during pregnancy and higher autism or ADHD risk. It may lower glutathione, an important antioxidant for brain development. Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.