How to Take Glutathione Effectively Methods & Tips Vitamin C vs Glutathione whats the difference? Both brighten the look of skin but they work in different ways. Vitamin C helps visibly brighten and improve the appearance of sun damage while Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic VITAMIN C GLUTATHIONE VITAMIN E Johnathan Edwards, M.D.