l Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway ScienceDirect OXIDATIVE STRESScan contribute to hypothyroid symptoms When the body has to deal with too much Oxidative Stress from inflammation, then the enzyme Glutathione Peroxidase [GPx] has to work overtime to inactivate damaging " Sulfur metabolism under stress: Oxidized glutathione inhibits methionine biosynthesis by destabilizing the enzyme cystathionine < em> synthase The Role of Glutathione Metabolism in Chronic Illness Development and Its Potential Use as a Novel Therapeutic Target Cureus