In patients with liver disease, acetaminophen metabolism is altered: the half life may be prolonged, and glutathione stores may be reduced, Therefore, acetaminophen can be used safely at reduced doses What is Acetaminophen Uses, Dangers, Risks, & More Rubicon Acetaminophen decreases intracellular glutathione levels and modulates cytokine production in human alveolar macrophages and typ Cytoprotective potential of tiron and methyl palmitate against acetaminophen induced acute liver injury