HERPES VIRUSES reactivation Sequence of events** When a person is suffering from chronic stress, excess Cortisol and Adrenaline with lowered Glutathione. Glutathione is the body's most important antioxidant. Insufficient Glutathione reduces the Herpes simplex virus protein UL56 inhibits cGAS Mediated DNA sensing to evade antiviral immunity ScienceDirect Cold sore triggers vary from person to person, but HSV is an opportunistic infection. That means it rears its ugly head when, for whatever reason, your immune system is too weak to Researchers Now Understand How a New Class of Antivirals Works Harvard Medical School