Could Tylenol be making your child's health worse? Acetaminophen is widely used for pain and fever relief, but research suggests it depletes glutathione, a powerful antioxidant essential for immune function, Tylenol and Glutathione: A Closer Look At Their Relationship Figure 1 from Acetaminophen toxicity and 5 oxoproline (pyroglutamic acid): a tale of two cycles, one an ATP depleting futile cycle and the other a useful cycle. Semantic Scholar Tylenol and Glutathione: A Closer Look At Their Relationship