The conjugation of acetaminophen by glutathione and cytochrome P450. Download Scientific Diagram Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Dr. Laura E. Riley joined @GoodMorningAmerica recently to clear up some lingering confusion about Tylenol (acetaminophen) use during pregnancy. A new study from the University of London found that acetaminophen is safe Does Acetaminophen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA