The FDA is signaling that perhaps immediate treatment with acetaminophen is less clearly needed for a low grade fever, especially in pregnancy, unless theres a stronger indication for it., Safer Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg kg intravenous acetaminophen in very preterm infants Pediatric Research Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen Pathway (therapeutic doses), Pharmacokinetics