Do statins prevent or cause heart disease? Personalized statin therapy: Targeting metabolic processes to modulate the therapeutic and adverse effects of statins: Heliyon The cardioprotective actions of statins in targeting mitochondrial dysfunction associated with myocardial ischaemia reperfusion injury ScienceDirect How One Pill Slows Down Cholesterol at Its Source Statins lower cholesterol by blocking the liver's cholesterol factory. Inside the liver, an enzyme called HMG CoA reductase is responsible for making cholesterol. Statins