Metabolite characterization of ambrisentan, in in vitro and in vivo matrices by UHPLC QTOF MS MS: Detection of glutathione conjugate of epoxide metabolite evidenced by in vitro GSH trapping assay Semantic Scholar Endogenous intracellular glutathionyl radicals are generated in neuroblastoma cells under hydrogen peroxide oxidative stress. In Vitro Trapping and Screening of Reactive Metabolites Using Liquid Chromatography Mass Spectrometry Springer Nature Link Current Insights into Glutathione Depletion in Adult Septic Patients