Dental Update Malignant oral melanoma: how to spot it and how it is managed Dental Update In the process of removing a Labial Melanotic Macule. A Labial Melanotic Macule is a well defined, oval, brown to black, flat patch on the central third of the lower lip, as seen Clinical Challenge: Dark Lesion on Lower Lip MPR Definition of melanocytic macules associated with Peutz Jeghers syndrome NCI Dictionary of Genetics Terms NCI