Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which The Use and Potential Benefits of N Acetylcysteine in Non Acetaminophen Acute Liver Failure: An Etiology Based Review Sex differences in glutathione metabolism and acetaminophen toxicity Figure 1: CMAJ
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glutathione and tylenol toxicity Acetaminophen Toxicity / Poisoning