Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which Tylenol's Impact on Glutathione and Liver Damage Acetaminophen (Paracetamol) Springer Nature Link What is Acetaminophen Uses, Dangers, Risks, & More Rubicon
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