Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen Use During Pregnancy and Neurodevelopmental Risk: Biological Plausibility1 Journal of Obstetrics and Gynaecology Canada Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Acetaminophen, also known as Tylenol, is used to help with pain & to reduce fever. However, taking too much acetaminophen can be harmful to the liver which filters out toxins &