The 7 Best Glutathione Foods Foods Highest in Glutathione Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open label, single arm, multicenter, pilot study BMC Gastroenterology Springer Nature Link Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Benefits of Glutathione