Oral Malignant Melanoma Oral Cancer Foundation Information and Resources about Oral Head and Neck Cancer Labial melanotic macule LABIAL LENTIGO, Labial Lentigo also called a labial melanotic macule, is a harmless, small, flat, brown spot on the lip. It can develop after repeated sun exposure. In most cases, labial lentigo This patient has multiple labial melanotic macules. These are essentially freckles of the lips. These most commonly involve the lower lip. This patient had involvement of both the upper and lower lips.