Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. The Truth About Why Most Glutathione Supplements Don't Work! Synergy Institute Acupuncture & Chiropractic sagesteele @P_McCulloughMD While I dont know whether there is a connection between Tylenol and autism, I do believe that there is reason to STOP giving it to babies children. Glutathione is impacted by Mechanism of acetaminophen induced hepatotoxicity. High dose of Download Scientific Diagram