Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted Small Molecule AngIV based Analogs to Treat Alzheimers Disease Adult hippocampal neurogenesis and cognitive flexibility linking memory and mood Nature Reviews Neuroscience Synaptogenesis Springer Nature Link
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