Pharmacology 401 k Paracetamol NAPQI Glutathione COX3 Poisoning Antidote AcetylCysteine YouTube The Metabolism of Acetaminophen and the Synthesis of Glutathione Download Scientific Diagram Paracetamol (acetaminophen) toxicity occurs when the liver is overwhelmed by a toxic metabolite called N acetyl p benzoquinone imine (NAPQI), which is normally detoxified by glutathione. In overdose, glutathione is depleted, and NAPQI accumulates, leading Clinical toxicity of Acetaminophen
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