In G6PD deficiency (XR), we have increased oxidative damage to RBCs, leading to intravascular hemolysis with decreased serum haptoglobin. We have decreased NADPH production, which means decreased conversion of oxidized ( S S ) glutathione Hepatic Glucose 6 Phosphate Dehydrogenase (G6PD) plays a pivotal role in the Pentose Phosphate Pathway, generating NADPH for antioxidant defense and supporting nucleotide & amino acid biosynthesis. Glucose 6 Phosphate Dehydrogenase Deficiency Glucose 6 Phosphate Dehydrogenase: Update and Analysis of New Mutations around the World
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glutathione and g6pd Glucose-6-phosphate dehydrogenase deficiency